Which cell is capable of cross-presentation?
It is increasingly clear that not only DCs and macrophages can cross-present antigens, but also many other endocytic cell types are capable of cross-presentation, including monocytes (70, 71), B cells (72), neutrophils (73), and endothelial cells (74).
What are CD8+ DCs?
The mouse CD8(+) DCs are non-migrating resident DCs derived from a precursor, distinct from monocytes, that continuously seeds the lymphoid organs from bone marrow.
Do dendritic cells express MHC Class 1 and 2?
MHC II molecules are expressed on immune cells such as B cells, monocytes, macrophages and dendritic cells and on epithelial cells following inflammatory signals, while MHC I molecules are expressed more ubiquitously.
What is antigen presentation pathway?
This antigen presentation pathway enables the immune system to detect transformed or infected cells displaying peptides from modified-self (mutated) or foreign proteins.
What is the difference between the antigens recognized by CD8+ and CD4+ T cells?
Antigen Presentation Another difference between CD4 and CD8 T cells is that the CD4 T cells recognize antigens on the surface of the antigen-presenting cells while the CD8 T cells recognize antigens on the surface of all nucleated cells.
Why do T cells express MHC?
Abstract. The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4(+) T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response.
Do CD8 T cells express MHC?
Because murine CD8 T cells do not transcribe MHC class II (MHC-II) genes, several models have proposed antigen presenting cells (APCs) as intermediaries required for CD4 T cells to deliver their help to CD8 T cells.
What is MHC I Cross-presentation and why is it important?
MHC I cross-presentation allows immune surveillance of viral infection and cancers. Dendritic cells utilize distinct and overlapping pathways for cross-presentation.
What is cross-presentation of exogenous antigens on MHC I molecules?
However, specialized antigen-presenting cells, such as DCs and macrophages, can present exogenous antigen on MHC-I in a process called cross-presentat … Cross-presentation of exogenous antigens on MHC I molecules
What is the MHC I pathway and how does it work?
The MHC I pathway is normally used to present endogenous antigens that have infected a particular cell. However, cross presenting cells are able to utilize the MHC I pathway in order to remain uninfected, while still triggering an adaptive immune response of activated cytotoxic CD8+ T cells against infected peripheral tissue cells.
Why is cross cross presentation important in immunology?
Cross presentation is also required for the induction of cytotoxic immunity by vaccination with protein antigens, for example, tumour vaccination.