What is the difference between Precedex and propofol?
Precedex and propofol are different types of sedatives. Precedex is an alpha2-adrenergic agonist and propofol is a sedative-hypnotic.
How do you transition from propofol to Precedex?
How to transition to dexmedetomidine:
- One hour after initiation of dexmedetomidine infusion, reduce narcotic dose by 50%
- Discontinue all other antipsychotics.
- Wean propofol and/or benzodiapines slowly as dose of dexmedetomidine is titrated upward.
When do you use Precedex?
1 INDICATIONS AND USAGE Precedex is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.
When should Precedex be used?
Precedex is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.
Can you give Precedex without intubation?
Dexmedetomidine may by useful in patients needing sedation without tracheal intubation. The literature suggests potential use of dexmedetomidine solely or as an adjunctive agent to other sedation agents.
What anesthesia can be used instead of propofol?
Fospropofol (Lusedra®) is a water-soluble, non-pyrogenic, iso-osmotic pro-drug sedative-hypnotic agent that is metabolized to propofol, and, if dosed appropriately, may be an alternate drug selection to propofol in some patients undergoing monitored anesthesia care (MAC).
Can Precedex be given to non intubated patients?
However, in late 2008, the FDA approved the use of dexmedetomidine for nonintubated patients requiring sedation prior to and/or during surgical and other procedures.
What is the alternative to propofol?
Is there a reversal agent for Precedex?
Atipamezole is a veterinary drug whose prime purpose is to reverse the effects of the sedative dexmedetomidine (as well as its racemic mixture, medetomidine).
When do you use precedex?
Does propofol or precedex cause more hypotension?
In a 2011 summary of Precedex safety data from RCTs analyzed by the the EMA (European FDA), the drug was found to be discontinued about 2% of the time for bradycardia and 1.5% of the time for hypotension, slightly more than propofol (0.4% brady and 1.1% hypotension) and significantly more than midazolam (0.3% and 0.3%) …
How much Precedex can you bolus?
The bolus dose of dexmedetomidine given will range from 0.25-2.0 mcg/kg and will be based on the up-and-down method, such that subject 1 will receive 0.5 mcg/kg and if no significant hemodynamic changes occur (heart rate decrease < 20% or blood pressure decrease/increase < 20%) the does will be increased by 0.25 mcg/kg …
Why is propofol preferred?
Propofol has many of the properties of an ideal anesthetic induction drug and is popular because it rapidly and smoothly induces anesthesia without airway irritation and results in a rapid recovery with an infrequent incidence of early PONV182 and a clear head.
Can you use precedex without intubation?
Can nurses administer precedex?
Registered nurses must complete a moderate sedation inservice and maintain yearly competency. Sedation nurses may then administer midazolam, Fentanyl, Demerol and morphine, under the physician’s direction.
Can you IV push Precedex?
Precedex infusion should not be co-administered through the same intravenous catheter with blood or plasma because physical compatibility has not been established. Precedex has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam.
Precedex and propofol are different types of sedatives. Precedex is an alpha2-adrenergic agonist and propofol is a sedative -hypnotic. What Are Possible Side Effects of Precedex? Common side effects of Precedex include: fluid in the lungs.
Do you use propofol or ketamine with Precedex?
We don’t use benzos due to increased delirium so its Propofol if the blood pressure will stand it or Precedex if not. If the patient gets bradycardic on Precedex then we usually add Ketamine.
What is the dosing for Precedex?
Precedex dosing should be individualized and titrated to desired clinical response. Precedex is not indicated for infusions lasting longer than 24 hours. Precedex should be administered using a controlled infusion device. For adult patients: a loading infusion of one mcg/kg over 10 minutes.
What is the difference between dexmedetomidine and propofol?
There was no difference seen in discharge status between either treatment group, with 84.8% in the dexmedetomidine group and 72.7% in the propofol group (P= NS) being discharged to home or self-care. Table 2 Summary of study results. Variable