What is Sca-1 a marker for?
Sca-1 is the most common marker used to enrich adult murine hematopoietic stem cells (HSCs) [14, 15] and can be used to isolate a nearly pure HSC population when used in conjunction with additional markers [16, 17].
Which cells express Sca-1?
Cardiac progenitor cells (CPCs), which express Sca-1, are also found in human adult myocardium and the cells can divide and expand after myocardial infarction (Beltrami et al., 2001, 2003; Oh et al., 2003; Müller et al., 2005).
What is the function of Sca?
Sca-1 expression has been identified in putative stem/progenitor cell populations within the skeletal system13, mammary gland14, prostate15, dermis16, skeletal muscle17, and liver18. The functions of Sca-1 include the promotion of cell adhesion and proliferation that are critical for optimal hematopoietic activity12.
What is SCA1+?
SCA1+ Cells from the Heart Possess a Molecular Circadian Clock and Display Circadian Oscillations in Cellular Functions – PMC.
What is SCA in biology?
Spinocerebellar ataxia (SCA), previously known as autosomal dominant cerebellar ataxia, is a biologically robust group of close to 30 progressive neurodegenerative diseases.
What are LSK cells?
KSL cells in cell biology are an early form of mouse/murine hematopoietic stem cells. Characteristics are Kit (+), Sca-1 (+) and Lin (-). HSCs [Hematopoietic stem cells] in murine cultures show phenotypic markers as being CD34-, CD150+, and Flt3- for LTR [long-term reconstitution].
What is a SCA group?
The SCA Group are a leading supplier of access scaffolding and containment and associated services to the Marine and Commercial sectors. Our range of services are always carried out professionally by trained and certified operatives, and with unwavering attention to health and safety without exception.
How many kingdoms are in the SCA?
twenty
The SCA’s “Known World” is divided into twenty regions called kingdoms, and within the kingdoms there are hundreds of local SCA groups – Cantons, Shires, and Baronies. Your local group’s listing will describe the area it covers, list a local contact person, and may have a link to the local group’s website.
How do you diagnose SCA?
A definitive diagnosis of SCA can be made only with a genetic test. Genetic testing can confirm mutations of a known gene to cause SCA. The genetic test for MJD (SCA3) is highly accurate.
How do you test SCA?
Patient DNA is analyzed to determine the number of CAG trinucleotide repeats located within each allele of the five causative genes; an abnormally large number of CAG repeats is diagnostic for the disease. Two categories of tests are available: Spinocerebellar Ataxia Panel includes testing for all five types of SCA.
What group is SCA?
The Society for Creative Anachronism (SCA) is an international living history group with the aim of studying and recreating mainly Medieval European cultures and their histories before the 17th century.
Is Sca-1 a cosignaling molecule?
Abbreviation: Sca-1, stem cell antigen-1. Figure 1. A model for Sca-1 function in stem cells. We propose that Sca-1 is a cosignaling molecule that can modify the signaling capacity of a receptor complex. In the context of a self-renewal signal, the presence of Sca-1 will generate more functional signaling complexes.
What is the function of Sca-1 in stem cells?
Figure 1. A model for Sca-1 function in stem cells. We propose that Sca-1 is a cosignaling molecule that can modify the signaling capacity of a receptor complex. In the context of a self-renewal signal, the presence of Sca-1 will generate more functional signaling complexes.
What is Sca-1 ataxia?
For the neurodegenerative disorder, see spinocerebellar ataxia type 1. Sca-1 stands for ” Stem cells antigen -1″ (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol -anchored cell surface protein (GPI-AP) of the LY6 gene family.
Is Sca-1 a good marker for murine hematopoietic stem cells?
The realization that many different stem cell types share conserved biochemical pathways has led to a flood of recent research using Sca-1 as a candidate marker in the search for tissu … Cloned 20 years ago, stem cell antigen-1 (Sca-1) is used extensively to enrich for murine hematopoietic stem cells.