What is an example of an immune complex mediated disease?
The clinical manifestations of the immune-complex mediated disease depend on the type of antigen and route of exposure. For example, intravenous entry of antigen can lead to vasculitis, arthritis, and glomerulonephritis. Inhalational entry can manifest with a pulmonary syndrome termed hypersensitivity pneumonitis.
What does the term immune complex mean?
Medical Definition of immune complex : any of various molecular complexes formed in the blood by combination of an antigen and an antibody that tend to accumulate in bodily tissue and are associated with various pathological conditions (as glomerulonephritis, vasculitis, and systemic lupus erythematosus)
Which of the following is an example of a type III immune complex disease?
A type III hypersensitivity reaction is also called immune complex disease. Examples of type III reactions include the Arthus reaction and serum sickness. The damage associated with type III reactions is mediated by the generation of hapten-specific antibody, primarily IgG.
Which is an immune system complex disease of the kidneys?
Lupus nephritis is predominantly an immune complex disease. Antibody-antigen complexes may form in the peripheral circulation and then be deposited within the kidney, or unbound antigens may first be planted within the renal parenchyma with later in situ antibody binding.
What causes immune complex?
An immune complex is formed from the integral binding of an antibody to a soluble antigen. The bound antigen acting as a specific epitope, bound to an antibody is referred to as a singular immune complex.
What is immune complex used for?
Immune complexes, particularly those made of IgG, also play a variety of roles in the activation and regulation of phagocytes, which include dendritic cells (DCs) and macrophages. Immune complexes are better at inducing DC maturation than an antigen on its own.
What is an example of Type 3?
Examples of type III hypersensitivity reactions include drug-induced serum sickness, farmer’s lung and systemic lupus erythematosus.
What are immune complexes made of?
An immune complex, sometimes called an antigen-antibody complex or antigen-bound antibody, is a molecule formed from the binding of multiple antigens to antibodies. The bound antigen and antibody act as a unitary object, effectively an antigen of its own with a specific epitope.
What do immune complexes consist of?
Introduction: Immune complexes are macromolecules consisting of immunoglobulins (antibodies) bound to different antigens [1]. Determination of circulating immune complexes in patients with malignant diseases can be of some interest for prognosis and follow-up of a disease [2, 3].