What does ASC-h mean on a Pap smear?
A finding of abnormal cells in a Pap test. It means there are abnormal squamous cells in the tissue that lines the outer part of the cervix. ASC-H may be a sign of a high-grade squamous intraepithelial lesion (HSIL), which may become cervical cancer if untreated. More testing may be needed.
How common is ASC-H?
Smears suggesting ASC-H are extremely rare with a reported rate of less than0. 5% of all interpretations (You et al., 2010; Cetiner et al., 2013). Management of abnormal cervical cytology mainly depends on the risk of underlying significant cervical histopathology found in each abnormal smear category.
Are ASCUS and LSIL the same?
ASC-US stands for atypical squamous cells of undetermined significance. “Squamous” refers to the type of cells that make up the tissue that covers the cervix. LSIL—This means that the cervical cells show changes that are mildly abnormal. LSIL usually is caused by an HPV infection that often goes away on its own.
Is ASC-H serious?
ASC-H primarily affects the squamous metaplastic cells. The cells display abnormal changes, but they cannot be definitively diagnosed as a high-grade squamous lesion. Patients with ASC-H are at higher risk of developing a precancerous lesion.
Should I be worried about ASC-H?
Conclusion: The diagnosis of ASC-H on Pap smear is associated with an appreciable risk of clinically significant disease. Patients with an ASC-H Pap smear result should undergo timely colposcopic and histologic assessment to rule out HSIL, AIS, and cervical cancer.
What is worse ASCUS or LSIL?
This means your Pap smear results are borderline, between normal and abnormal. ASC-H (Atypical squamous cells of undetermined significance-cannot exclude HSIL). This means your Pap smear results are borderline but may be more serious. LSIL (Low grade squamous intraepithelial lesion).
How often does LSIL turn into HSIL?
Untreated LSIL can progress in 13% of cases to HSIL during 2 years of monitoring (9,10). Women infected with HPV 16 have a transition of LSIL into HSIL in 9% of cases.
Can ASC-H be nothing?
ASC-H. ASC-H stands for atypical squamous cells, cannot exclude HSIL. It basically means that the healthcare providers are having trouble making a diagnosis.
Is ASCUS or LSIL worse?
Is ASC-H worse than LSIL?
LSIL-H had a higher chance of association with high grade dysplasia on biopsy, comparable to that for ASC-H (Positive predictive value [PPV] of 33% with LSIL-H and 31% with ASC-H). LSIL alone was associated with a significantly lower risk (PPV 10%) for high grade dysplasia as compared to LSIL-H (PPV 33%).
How long does it take for LSIL to turn into HSIL?
Is ASC-H precancer?
Does having LSIL mean I have HPV?
LSILs look slightly abnormal when looked at under a microscope. They are usually caused by infection with certain types of human papillomavirus (HPV) and are found when a Pap test or biopsy is done. LSILs usually go away on their own without treatment, but sometimes they can become cancer and spread into nearby tissue.
What is the prognosis of ASC-h with HSIL?
In some cases, women having ASC-H findings may harbor HSIL or invasive cervical cancer in their follow up. Of all women with HSIL results, 2% or less have invasive cervical cancer at the time of diagnosis. About 20% can however, progress to have invasive cervical cancer if not treated or followed appropriately.
What are the ASC-h and ASC-US guidelines for Colposcopy?
The American Society Colposcopy and Cervical Pathology (ASCCP) guidelines recommend immediate colposcopic evaluation. ASC-H is more likely than ASC-US to be caused by a pre-cancerous lesion and a colposcopy should be done. Women with Low-Grade Squamous Lesion (LSIL) on their PAP require further testing.
What is the difference between HSIL and LSIL?
LSIL is now recommended to be used as a diagnostic category to describe HPV transient infection-related changes, while HSIL is used to categorize true precancerous lesion. [ 2]
When is a Pap smear indicated in the workup of ASC-US?
For example, cases of ASC-US with atrophic cellular pattern/atrophic vaginitis may benefit from repeating the Pap smear after estrogen therapy (systemic or local). Similarly, ASC-US in association with infection may benefit from repeating the Pap smear after treating the infection.