What is the antidote for doxorubicin extravasation?
A significant portion of doxorubicin was extravasated. Dexrazoxane was prescribed as an antidote. Side effects of dexrazoxane were restricted to reversible hematological toxicity, nausea, and vomiting.
How do you use DMSO in extravasation?
Procedure
- ensure the skin is dry before applying DMSO 99% solution (if skin is wet or DMSO 99% solution is applied with wet gloves, it will cause the skin to blister)
- apply a thin layer of DMSO 99% solution topically to the area of extravasation (use sparingly):
- Allow to air dry; do not cover with a dressing.
What is the best treatment for extravasation?
Generally cold compresses are recommended for extravasation of all irritant and vesicant drugs except vinca alkaloids (vincristine, vinblastine, vinorelbine), epipodophyllotoxins (etoposide), oxaliplatin, and vasopressors, as cold worsens tissue ulceration caused by these drugs.
Is Adriamycin a vesicant?
Doxorubicin is administered via an intravenous (IV) injection through a central line or a peripheral venous line, and the drug is given over several minutes. Doxorubicin can also be given by continuous infusion through a central catheter line. There is no pill form of Doxorubicin. Doxorubicin is a vesicant.
What is the difference between extravasation and infiltration?
The difference between an infiltration and extravasation is the type of medicine or fluid that is leaked. Infiltration – if the fluid is a non-vesicant (does not irritate tissue), it is called an infiltration. Extravasation – if the fluid is a vesicant (a fluid that irritates tissue), it is called an extravasation.
What skin complications are associated with extravasation?
Proper monitoring and immediate intervention will go a long way in minimizing the morbidity associated with these injuries. However, if there is a delay in recognition and treatment, it can lead to complications like skin necrosis, gangrene, extensive soft tissue defects and contractures.
What happens if chemo leaks into tissue?
Fluid leaking into surrounding tissue But some chemotherapy drugs can cause damage to the tissues if they leak. These drugs are called vesicants. A vesicant drug that leaks can cause pain and ulceration to the body tissues. This doesn’t necessarily happen straight away.
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