Does telomerase regulate proliferation?
Telomerase Activity Is Correlated with Cell Proliferation in Normal Human Tissues Cells and Tumors. Although telomerase was proposed to be expressed in tumor and not normal human tissue, evidence has accumulated that telomerase is expressed in a variety of normal tissues and that it is growth-regulated.
What does the telomerase extend?
Some cells have the ability to reverse telomere shortening by expressing telomerase, an enzyme that extends the telomeres of chromosomes. Telomerase is an RNA-dependent DNA polymerase, meaning an enzyme that can make DNA using RNA as a template.
What is telomerase expression?
Expression of telomerase is usually required for cell immortalization and long-term tumor growth. In humans, telomerase activity is tightly regulated during development and oncogenesis. The modulation of telomerase activity may therefore have important implications in antiaging and anticancer therapy.
Does telomerase lengthen or shorten telomeres?
Length of telomeric DNA is important for lifespan of a cell This enzyme is active in germline and stem cells and maintains their telomere length by adding ‘TTAGGG’ repeats to the ends of chromosomes. Therefore, telomeres do not shorten in these types of cells. (b) Telomerase is inactive in normal somatic cells.
What is the role of telomerase?
Telomerase is a large ribonucleoprotein complex responsible for progressive synthesis of telomeric DNA repeats (TTAGGG) at the 3′ ends of linear chromosomes, thereby reversing the loss of DNA from each round of replication.
What end does telomerase extend?
3′ end
Telomerase adds complementary RNA bases to the 3′ end of the DNA strand. Once the 3′ end of the lagging strand template is sufficiently elongated, DNA polymerase adds the complementary nucleotides to the ends of the chromosomes; thus, the ends of the chromosomes are replicated.
Does lengthening telomeres increase lifespan?
Telomeres help protect the genetic material inside the DNA. As we age telomeres shorten with each cell division until they cannot divide anymore. The longer the telomere length, the longer the lifespan.
What is the function of telomerase quizlet?
Telomerase allows for telomere length and equilibrium maintenance by adding on repeats to the end of the chromosome.
What is the role of telomerase quizlet?
How exactly does telomerase extend telomeres quizlet?
What does the enzyme telomerase do?
An enzyme in cells that helps keep them alive by adding DNA to telomeres (the ends of chromosomes). Each time a cell divides, the telomeres lose a small amount of DNA and become shorter. Over time, the chromosomes become damaged and the cells die.
What is the biological function of telomerase?
Telomerase plays a key role in maintaining the elongation of the 3′ DNA template at the end of the chromosome, thus compensating for the telomere shortening that occurs in the absence of this activity.
What is the function of telomerase?
Which best describes the function of telomerase?
What best describes the function of telomerase at the telomere? It adds new DNA to the longer strand of the telomere overhang.
What is the function of telomerase in DNA replication quizlet?
telomerase adds DNA nucleotides to the overhang and DNA polymerase extends the complimentary strand.
What is telomerase and explain its function quizlet?
How do you extend the life of telomeres?
Some tips for how you can help slow down telomere shortening include:
- Maintain a healthy weight with healthy eating.
- Exercise regularly.
- Quit smoking.
- Get enough sleep.
- Reduce or manage stress.
- Eat a telomere-protective diet full of foods high in vitamin C, polyphenols, and anthocyanins.
What is telomere sequence explain its role and synthesis in human cells?
The ends of the linear chromosomes are known as telomeres: repetitive sequences that code for no particular gene. These telomeres protect the important genes from being deleted as cells divide and as DNA strands shorten during replication. In humans, a six base pair sequence, TTAGGG, is repeated 100 to 1000 times.
What is the role of telomerase in DNA replication quizlet?
What is the function of the telomerase enzyme?
Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes and stem and tumor cells.