How does amputation affect creatinine clearance?
In particular, serum creatinine is signifi- cantly reduced while creatinine clearance is overestimated in patients with amputations. The “missing” body part must be accounted for when executing a dosing regimen for these chal- lenging patients.
How does amputation affect GFR?
The investigation of the changes after amputation as a reflection of post-operative recovery showed that GFR estimates decreased significantly from post-operative day 5 to post-operative day 10 for both CKD-EPICystatinC (−6.8 mL/min/1.73m2, 95% CI: −9.7; −3.8, p < 0.01) and CKD-EPICombined (−4.5 mL/min/1.73 m2, 95% CI: …
Can I have surgery if I have kidney disease?
Surgical procedures are frequently necessary in patients with chronic kidney disease who are not yet undergoing dialysis and in patients with end-stage renal disease who are undergoing dialysis. Access for dialysis accounts for the vast majority of these procedures.
How do you calculate BSA in an amputee?
When calculating the dose of chemotherapy in the presence of amputation, many physicians borrow the rule of nines from burn medicine as a way to estimate BSA. The rule provides a practical estimate for the percentage of BSA and divides the body into areas of roughly 9% of BSA.
What is the difference between GFR and CrCl?
Creatinine clearance ( CrCl ) is an estimate of Glomerular Filtration Rate ( GFR ); however, CrCl is slightly higher than true GFR because creatinine is secreted by the proximal tubule (in addition to being filtered by the glomerulus). The additional proximal tubule secretion falsely elevates the CrCl estimate of GFR .
Is Propofol hard on the kidneys?
This medicine may cause propofol infusion syndrome, which can lead to more serious problems (eg, high potassium in the blood, high fat or cholesterol in the blood, rhabdomyolysis, enlarged liver, kidney failure, heart failure).
How do you calculate the nutritional needs of an amputee?
For a man, use 106 pounds for the first 5 feet and then add 6 pounds for each additional inch: 106 lbs + (6 lbs per inch x 8 inches) = 154 pounds. This 5 foot, 8 inch patient with an entire arm amputation has an Ideal Body Weight range goal of approximately 161 lbs to 132 lbs.
What is normal CrCl?
Normal values are: Male: 97 to 137 mL/min (1.65 to 2.33 mL/s). Female: 88 to 128 mL/min (14.96 to 2.18 mL/s).
What is difference between GFR and eGFR?
GFR is Glomerular Filtration Rate and it is a key indicator of renal function. eGFR is estimated GFR and is a mathematically derived entity based on a patient’s serum creatinine level, age, sex and race.
What does mL/min/1.73 m2 mean?
What do eGFR numbers mean? Healthcare providers measure eGFR in milliliters of cleansed blood per minute per body surface (a measurement that reads mL/min/1.73m2). Values for eGFR vary depending on age, sex and other factors. The rate naturally declines as you age and lose muscle mass.
What is propofol overdose?
Overdose. Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. Propofol can cause severe drowsiness or dizziness, which may last for several hours. You will need someone to drive you home after your surgery or procedure.
What is the most nephrotoxic antibiotic?
Two antibiotics associated with nephrotoxicity that are used to treat dangerous resistant infections are vancomycin and colistin.
Is ACE inhibitor nephrotoxic?
ACE inhibitors are not nephrotoxic. Baseline serum creatinine levels of up to 3.0 mg per dL (27 μmol per L) are generally considered safe.